DESIGN, SYNTHESIS, CHARACTERIZATION, AND ANTI-MICROBIAL AND INFLAMMATORY ACTIVITY OF NOVEL 3-CHLORO-2-OXO-4-SUBSTITUTED PHENYLAZETIDINONE AND 2-SUBSTITUTED PHENYLTHIAZOLIDINONE-1, 8- NAPHTHALIMIDE DERIVATIVE SPACERS

被引：0

作者：

Sirgamalla, Rambabu ^{[1
]}

Devaram, J. ^{[1
]}

Konduru, Sumalatha ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana, India

来源：

HETEROCYCLIC LETTERS | 2020年 / 10卷 / 01期

关键词：

1,8-Naphthalimides; Schiff bases; 3-Chloro-2-azetidinones; 4-Thiozolidinones; antimicrobial; anti-inflammatory; molecular docking; DNA; 1,3,4-OXADIAZOLES; 1,8-NAPHTHALIMIDE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 1, 8-naphthalimide-3-Chloro-2-azetidinones and 4-thiozolidinones via corresponding Schiff bases,Theseare synthesized from2-(4-aminophenyl)-1H-benzo[de] isoquinoline-1, 3(2H)dione andvarious aryl aldehydes were novel analogues synthesized and pursuing our recent interest regarding antimicrobial and anti-inflammatory activities. All the synthesized compounds show excellent anti-inflammatory activity against both MMP-2 and MMP-9 gelatinase zymography, whereas considerable good activity against Gram-positive and Gram-negative bacterial strains and antifungal activity. Moreover all the synthesized compounds were docked against1JXA -Glucosamine-6-phosphatsynthese: Co-crystal, 3LPS-Topoisomerase IV,3TTZ-Gyrase enzymes.

引用

页码：97 / 107

页数：11

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