Iodine-Catalyzed Versatile Synthesis of 4,6-Diarylpyrimidin-2(1H)-ones (DAPMs) via One-Pot, Multicomponent Reaction

被引：18

作者：

Reddy, M. B. Madhusudana ^{[1
]}

Pasha, M. A. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Bengaluru 560001, India

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 13期

关键词：

Aldehyde; 4; 6-diarylpyrimidin-2(1h)-one; iodine; ketone; solvent-free reaction; urea; EFFICIENT SYNTHESIS; BLOCKERS; ACID;

D O I：

10.1080/00397911.2010.493263

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[image omitted] An efficient, solvent-free, one-pot, three-component cyclocondensation reaction between aldehyde, ketone, and urea to give 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using iodine as catalyst is described. This new protocol provides a simple and environmentally benign route along with the associated advantages of good to excellent yield of the products (90-96%) and short reaction times (5-15min) at 80 degrees C.

引用

页码：1875 / 1880

页数：6

共 23 条

[21] CALCIUM-ENTRY BLOCKERS AND ACTIVATORS - CONFORMATIONAL AND STRUCTURAL DETERMINANTS OF DIHYDROPYRIMIDINE CALCIUM-CHANNEL MODULATORS [J].

ROVNYAK, GC ;

KIMBALL, SD ;

BEYER, B ;

CUCINOTTA, G ;

DIMARCO, JD ;

GOUGOUTAS, J ;

HEDBERG, A ;

MALLEY, M ;

MCCARTHY, JP ;

ZHANG, RA ;

MORELAND, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (01) :119-129

[22] Novel Biginelli-like three-component cyclocondensation reaction:: efficient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones [J].

Wang, ZT ;

Xu, LW ;

Xia, CG ;

Wang, HQ .

TETRAHEDRON LETTERS, 2004, 45 (42) :7951-7953

[23]

Wender PA, 1997, CHEM IND-LONDON, P765

← 1 2 3 →