Interchromosomal interactions: A genomic love story of kissing chromosomes

被引：87

作者：

Maass, Philipp G. ^{[1
,6
]}

Barutcu, A. Rasim ^{[1
,2
,7
]}

Rinn, John L. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[2] Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02142 USA

[3] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[4] Beth Israel Deaconess Med Ctr, Dept Pathol, 330 Brookline Ave, Boston, MA 02215 USA

[5] Univ Colorado, Dept Biochem, BioFrontiers, Boulder, CO 80309 USA

[6] Hosp Sick Children, Genet & Genome Biol Program, Peter Gilgan Ctr Res & Learning, Toronto, ON, Canada

[7] Univ Toronto, Donnelly Ctr, Toronto, ON, Canada

来源：

JOURNAL OF CELL BIOLOGY | 2019年 / 218卷 / 01期

基金：

美国国家卫生研究院;

关键词：

INTRINSICALLY DISORDERED REGIONS; CONFORMATION CAPTURE; TRANSCRIPTION FACTORIES; SPATIAL-ORGANIZATION; X-INACTIVATION; 3D GENOME; TERRITORY ARRANGEMENTS; NUCLEAR-ORGANIZATION; TOPOLOGICAL DOMAINS; SEQUENCING REVEALS;

D O I：

10.1083/jcb.201806052

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclei require a precise three- and four-dimensional organization of DNA to establish cell-specific gene-expression programs. Underscoring the importance of DNA topology, alterations to the nuclear architecture can perturb gene expression and result in disease states. More recently, it has become clear that not only intrachromosomal interactions, but also interchromosomal interactions, a less studied feature of chromosomes, are required for proper physiological gene-expression programs. Here, we review recent studies with emerging insights into where and why cross-chromosomal communication is relevant. Specifically, we discuss how long noncoding RNAs (lncRNAs) and three-dimensional gene positioning are involved in genome organization and how low-throughput (live-cell imaging) and high-throughput (Hi-C and SPR ITE) techniques contribute to understand the fundamental properties of interchromosomal interactions.

引用

页码：27 / 38

页数：12

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