Synthesis and incorporation of carbocyclic nucleosides into a hammerhead ribozyme domain-RNase resistance and catalytic activity

被引：7
|
作者：
Burlina, F
Favre, A
Fourrey, JL
Thomas, M
机构：
[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
[2] UNIV PARIS 07,CNRS,INST JACQUES MONOD,F-75251 PARIS 05,FRANCE
来源：
CHEMICAL COMMUNICATIONS | 1996年 / 14期
关键词：
D O I：
10.1039/cc9960001623
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A hammerhead ribozyme domain incorporating (-)-carbodine 8a and (-)-aristeromycin 8b at selected positions, manifests increased RNase resistance and exhibits significant catalytic activity.
引用
收藏
页码：1623 / 1624
页数：2
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