Models in the Research Process of Psoriasis

被引：109

作者：

Bochenska, Katarzyna ^{[1
]}

Smolinska, Elwira ^{[1
,2
]}

Moskot, Marta ^{[1
,3
]}

Jakobkiewicz-Banecka, Joanna ^{[1
]}

Gabig-Ciminska, Magdalena ^{[1
,3
]}

机构：

[1] Univ Gdansk, Dept Med Biol & Genet, Wita Stwosza 59, PL-80308 Gdansk, Poland

[2] Med Univ Gdansk, Dept Physiol, Debinki 1, PL-80211 Gdansk, Poland

[3] Polish Acad Sci, Inst Biochem & Biophys, Lab Mol Biol, Kladki 24, PL-80822 Gdansk, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 12期

关键词：

psoriasis; disease models; pathomechanism; biomedical tools; drug-development; NF-KAPPA-B; IN-VITRO MODEL; ANIMAL-MODELS; HUMAN KERATINOCYTES; SKIN-DISEASE; TRANSGENIC MICE; DRUG DISCOVERY; MOUSE MODEL; EPIDERMAL-KERATINOCYTES; UNINVOLVED SKIN;

D O I：

10.3390/ijms18122514

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis is an ancient, universal chronic skin disease with a significant geographical variability, with the lowest incidence rate at the equator, increasing towards the poles. Insights into the mechanisms responsible for psoriasis have generated an increasing number of druggable targets and molecular drugs. The development of relevant in vitro and in vivo models of psoriasis is now a priority and an important step towards its cure. In this review, we summarize the current cellular and animal systems suited to the study of psoriasis. We discuss the strengths and limitations of the various models and the lessons learned. We conclude that, so far, there is no one model that can meet all of the research needs. Therefore, the choice model system will depend on the questions being addressed.

引用

页数：17

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