Enrichment and Detection of Peptides from Biological Systems Using Designed Periodic Mesoporous Organosilica Microspheres

被引：37

作者：

Qian, Kun ^{[1
]}

Gu, Wenyi ^{[1
]}

Yuan, Pei ^{[1
]}

Liu, Fang ^{[2
]}

Wang, Yunhua ^{[2
]}

Monteiro, Michael ^{[1
]}

Yu, Chengzhong ^{[1
]}

机构：

[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

SMALL | 2012年 / 8卷 / 02期

关键词：

size-exclusive; organosilica; microspheres; E7; peptides; LOW-ABUNDANCE PEPTIDES; PROTEINS; PLASMA;

D O I：

10.1002/smll.201101770

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Periodic mesoporous organosilica microspheres (PMOMs) are designed with integrated structural features, including a cubic mesostructure, hydrophobic wall composition, a uniform pore size of ≈3 nm, and a spherical morphology in micrometers, all advantageous for size-selective and highly efficient enrichment of peptides from mixtures. Consequently, PMOMs can be used to capture peptides in a range of complex biological systems. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：231 / 236

页数：6

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