Contributions of the NICHD neonatal research network's generic database to documenting and advancing the outcomes of extremely preterm infants

被引:2
作者
Bell, Edward F. [1 ]
Stoll, Barbara J. [2 ,3 ]
Hansen, Nellie, I [4 ]
Wyckoff, Myra H. [5 ]
Walsh, Michele C. [6 ]
Sanchez, Pablo J. [7 ]
Rysavy, Matthew A. [3 ]
Gabrio, Jenna H. [8 ]
Archer, Stephanie W. [6 ]
Das, Abhik [9 ]
Higgins, Rosemary D. [10 ]
机构
[1] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA
[2] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA
[3] McGovern Med Sch UTHlth, Dept Pediat, Houston, TX USA
[4] RTI Int, Social Stat & Environm Sci Unit, Res Triangle Pk, NC USA
[5] Univ Texas Southwestern Dallas, Dept Pediat, Dallas, TX USA
[6] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA
[7] Ohio State Univ, Coll Med, Dept Pediat, Nationwide Childrens Hosp, Columbus, OH USA
[8] RTI Int, Social Stat & Environm Sci Unit, Berkeley, CA USA
[9] RTI Int, Social Stat & Environm Sci Unit, Rockville, MD USA
[10] Florida Gulf Coast Univ, Off Associate VP Res, Ft Myers, FL USA
基金
美国国家卫生研究院;
关键词
Neonatal Research Network; NICHD; Neonatal clinical trials; Generic Database; BIRTH-WEIGHT INFANTS; LATE-ONSET SEPSIS; NATIONAL-INSTITUTE; CHILD-HEALTH; NEURODEVELOPMENTAL OUTCOMES; NECROTIZING ENTEROCOLITIS; RANDOMIZED-TRIAL; GROWTH OUTCOMES; INTENSIVE-CARE; MORTALITY;
D O I
10.1016/j.semperi.2022.151635
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) maintains a database of extremely preterm infants known as the Generic Database (GDB). Begun in 1987, this database now includes more than 91,000 infants, most of whom are extremely preterm (<29 weeks gestation). The GDB has been the backbone of the NRN, providing high quality, prospectively collected data to study the changing epidemiology of extreme prematurity and its outcomes over time. In addition, GDB data have been used to generate hypotheses for prospective studies and to develop new clinical trials by providing information about the numbers and characteristics of available subjects and the expected event rates for conditions and complications to be studied. Since its inception, the GDB has been the basis of more than 200 publications in peer-reviewed journals, many of which have had a significant impact on the field of neonatology. (c) 2022 Elsevier Inc. All rights reserved.
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页数:8
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