An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges

被引:17
作者
Xu, Xiaoying [1 ]
Chen, Yuheng [3 ]
Lu, Xinyu [2 ]
Zhang, Wanlin [2 ]
Fang, Wenxiu [2 ]
Yuan, Luping [2 ]
Wang, Xiaoyan [2 ]
机构
[1] Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou 310053, Peoples R China
[2] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 311402, Peoples R China
[3] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Peoples R China
基金
中国国家自然科学基金;
关键词
COVID-19; SARS-CoV-2; Antiviral; RdRp; Inhibitors; BAICALEIN CHEWABLE TABLETS; SCUTELLARIA-BAICALENSIS; SARS-COV-2; REPLICATION; REMDESIVIR GS-5734; MOLECULAR-BASIS; ZIKA VIRUS; OPEN-LABEL; IN-VIVO; CORONAVIRUS; NUCLEOSIDE;
D O I
10.1016/j.bcp.2022.115279
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The highly transmissible variants of SARS-CoV-2, the causative pathogen of the COVID-19 pandemic, bring new waves of infection worldwide. Identification of effective therapeutic drugs to combat the COVID-19 pandemic is an urgent global need. RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication, is the most promising target for antiviral drug research since it has no counterpart in human cells and shows the highest conservation across coronaviruses. This review summarizes recent progress in studies of RdRp inhibitors, focusing on interactions between these inhibitors and the enzyme complex, based on structural analysis, and their effectiveness. In addition, we propose new possible strategies to address the shortcomings of current in-hibitors, which may guide the development of novel efficient inhibitors to combat COVID-19.
引用
收藏
页数:16
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