Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy

被引：33
|
作者：
Paciaroni, Nicholas G. [1 ]
Ndungu, John M. [1 ]
Kodadek, Thomas [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, 130 Scripps Way, Jupiter, FL 33458 USA
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 34期
基金：
美国国家卫生研究院;
关键词：
ORGANIC-SYNTHESIS; DOUBLE-BONDS; SELECTION; KETONES; GENERATION; OXIDATION; ALKYNES; DESIGN;
D O I：
10.1039/d0cc01474e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.
引用
收藏
页码：4656 / 4659
页数：4
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