Short stature in chronic kidney disease: Physiopathology and treatment with growth hormone

被引：3
作者：
Campos De Oliveira, Josenilson [2 ]
Siviero-Miachon, Adriana A. [3 ]
Spinola-Castro, Angela Maria [4 ]
Santoro Belangero, Vera Maria [5 ]
Guerra-Junior, Gil [1 ]
机构：
[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Pediat, Unidad Endocrinol Pediat, BR-13083970 Campinas, SP, Brazil
[2] Univ Estadual Campinas, Fac Ciencias Med, Med Clin, BR-13083970 Campinas, SP, Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Programa Posgrad Curso Pediat, Sao Paulo, Brazil
[4] Univ Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Unidade Endocrinol Pediat, Sao Paulo, Brazil
[5] Univ Estadual Campinas, Fac Ciencias Med, Dept Pediat, Unidade Nefrol Pediat, BR-13083970 Campinas, SP, Brazil
来源：
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2008年 / 52卷 / 05期
关键词：
chronic kidney failure; growth; growth hormone; corticoids; kidney dialysis; kidney transplantation;
D O I：
10.1590/S0004-27302008000500010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Growth failure is frequent and a clinically important issue in children with chronic kidney disease (CKD). Many factors contribute to impaired growth in these children, including abnormalities in the growth hormone (GH) - insulin-like growth factor 1 (IGF-1) axis, malnutrition, acidosis, renal bone disease and glucocorticoid associated treatment. The management of growth failure in children with CKD is complicated by the presence of other-disease related complications requiring medical intervention. Despite evidence of GH efficacy and safety in this population, this therapy is still underutilized. This review shows the impact, the causes and the treatment of growth failure in children with CKD.
引用
收藏
页码：783 / 791
页数：9
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