Beyond conventional routes, an unprecedented metal-free chemoselective synthesis of anthranilate esters via a multicomponent reaction (MCR) strategy

被引：9

作者：

Sarkar, Satavisha ^{[1
]}

Khan, Abu T. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 63期

关键词：

HOFMANN-TYPE REARRANGEMENT; TANDEM CATALYSIS; ATOM ECONOMY; CHEMISTRY; EFFICIENT; ACID; CARBONYLATION; ACTIVATION; BROMIDE; IMIDES;

D O I：

10.1039/c5cc03369a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hitherto unreported route for the synthesis of anthranilate esters is demonstrated using 2-nitrobenzaldehyde, malonitrile and an alcohol or amine via a metal and oxidant free multicomponent reaction (MCR) strategy. This process simultaneously installs an ester and urea or urethane functionality via CO and CN bond formations via concurrent oxidation of the aldehyde group and reduction of the nitro group involving an intramolecular redox process.

引用

页码：12673 / 12676

页数：4

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