An international perspective on hospitalized patients with viral community-acquired pneumonia

被引：24

作者：

Radovanovic, Dejan ^{[1
]}

Sotgiu, Giovanni ^{[2
]}

Jankovic, Mateja ^{[3
]}

Mahesh, Padukudru Anand ^{[4
]}

Jorge Marcos, Pedro ^{[5
]}

Abdalla, Mohamed I. ^{[6
,7
]}

Di Pasquale, Marta Francesca ^{[8
]}

Gramegna, Andrea ^{[8
]}

Terraneo, Silvia ^{[9
]}

Blasi, Francesco ^{[8
]}

Santus, Pierachille ^{[1
]}

Aliberti, Stefano ^{[8
]}

Reyes, Luis F. ^{[10
,11
]}

Restrepo, Marcos I. ^{[6
,7
]}

Noriega, Lorena

Alvarado, Ezequiel

Aman, Mohamed

Labra, Lucia

Karina Aruj, Patricia ^{[12
]}

Attorri, Silvia ^{[13
]}

Barimboim, Enrique ^{[14
]}

Pablo Caeiro, Juan ^{[15
]}

Garzon, Maria I. ^{[15
]}

Hugo Cambursano, Victor ^{[16
]}

Ceccato, Adrian ^{[17
]}

Chertcoff, Julio ^{[18
]}

Cordon Diaz, Ariel ^{[19
]}

de Vedia, Lautaro ^{[20
]}

Cristina Ganaha, Maria ^{[21
]}

Lambert, Sandra ^{[22
]}

Lopardo, Gustavo ^{[23
]}

Luna, Carlos M. ^{[24
]}

Gerardo Malberti, Alessio ^{[25
]}

Morcillo, Nora ^{[26
]}

Tartara, Silvina ^{[26
]}

Pensotti, Claudia ^{[27
]}

Pereyra, Betiana ^{[28
]}

Gustavo Scapellato, Pablo ^{[29
]}

Pablo Stagnaro, Juan ^{[30
]}

Shah, Sonali ^{[31
]}

Loetsch, Felix ^{[32
]}

Thalhammer, Florian ^{[32
]}

Anseeuw, Kurt ^{[33
]}

Francois, Camille A. ^{[34
]}

Van Braeckel, Eva ^{[35
]}

Vincent, Jean Louis ^{[36
]}

Djimon, Marcel Zannou ^{[37
]}

Nouer, Simone Aranha ^{[38
]}

Chipev, Peter ^{[39
]}

Encheva, Milena ^{[39
]}

机构：

[1] Univ Milan, Dept Biomed & Clin Sci DIBIC, Sect Resp Dis, Osped L Sacco,ASST Fatebenefratelli Sacco, Milan, Italy

[2] Univ Sassari, Dept Med Surg & Expt Med, Clin Epidemiol & Med Stat Unit, Sassari, Italy

[3] Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Resp Dis Jordanovac, Sch Med, Zagreb, Croatia

[4] JSS Acad Higher Educ & Res, JSS Med Coll, Dept Pulm Med, Mysore, Karnataka, India

[5] Univ Coruna UDC, Inst Invest Biomed Coruna INIBIC, Estruct Organizat Xest Integrada EOXI A Coruna, CHUAC,SERDAS,Direcc Proc Asistenciales,Serv Neumo, La Coruna, Spain

[6] South Texas Vet Hlth Care Syst, San Antonio, TX USA

[7] Univ Texas Hlth San Antonio, San Antonio, TX USA

[8] Univ Milan, Dept Pathophysiol & Transplantat, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Internal Med Dept,Resp Unit & Cyst Fibrosis Adult, Via Francesco Sforza 35, I-20122 Milan, Italy

[9] Univ Milan, Dept Hlth Sci, Milan, Italy

[10] Univ La Sabana, Dept Microbiol, Chia, Colombia

[11] Univ Milan, Resp Unit, San Paolo Hosp, Dept Hlth Sci, Milan, Italy

[12] Univ Hosp Alfredo Lanari, Dept Internal Med, Buenos Aires, DF, Argentina

[13] Hosp Luis Lago Maggiore, Mendoza, Argentina

[14] Hosp Cent Mendoza, Mendoza, Argentina

[15] Hosp Privado Univ, Cordoba, Argentina

[16] Hosp Rawson, Serv Neumol, VH Dr Cazaux A, Cordoba, Argentina

[17] Hosp Nacl Prof Alejandro Posadas, Buenos Aires, DF, Argentina

[18] Buenos Aires British Hosp, Crit Care Unit & Resp Med, Florencia Lascar & Fernando Di Tulio, Buenos Aires, DF, Argentina

[19] Hosp Gen Alvear, Mendoza, Argentina

[20] Hosp Muniz, Resp Intens Care Unit, Buenos Aires, DF, Argentina

[21] Hosp Interzonal Gen Agudos Vicente y Lopez Planes, Infect Dis Ward, Buenos Aires, DF, Argentina

[22] Hosp El Cruce, Alta Complejidad Red, Buenos Aires, DF, Argentina

[23] Hosp Bernardo Houssay, Vicente Lopez, Argentina

[24] Univ Buenos Aires, Hosp Clin, Dept Med, Pulm Med Div, Buenos Aires, DF, Argentina

[25] Hosp Nuestra Senora Carmen, La Rioja, Spain

[26] Hosp Zonal Especializado Agudos & Cronicos Dr Ant, Buenos Aires, DF, Argentina

[27] Clin Privada Monte Grande, Infect Dis & Infect Control Dept, Buenos Aires, DF, Argentina

[28] Hosp San Roque, Cordoba, Argentina

[29] Hosp DF Santojanni, Infect Dis Dept, Buenos Aires, DF, Argentina

[30] HZGA Mi Pueblo, Florencio Varela, Argentina

[31] Austin Hosp, Dept Gen Med, Heidelberg, Vic, Australia

[32] Med Univ Vienna, Dept Med 1, Div Infect Dis & Trop Med, Vienna, Austria

[33] ZNA Campus Stuivenberg, Antwerp, Belgium

[34] Erasme Univ Hosp, Anesthesia & Crit Care Dept, Brussels, Belgium

[35] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

[36] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Brussels, Belgium

[37] Ctr Hosp Univ HKM Cotonou, Jules Bashi & Roger Dodo, Cotonou, Benin

[38] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

[39] Mil Med Acad, Clin Pulm Dis, Sofia, Bulgaria

[40] UMHAT St Marina, Varna, Bulgaria

[41] Univ Hosp Varna, Varna, Bulgaria

[42] Yaounde Jamot Hosp, Yaounde, Cameroon

[43] Univ Yaounde, Dept Med Interne, Yaounde, Cameroon

[44] Douala Gen Hosp, Douala, Cameroon

[45] Peking Univ, Hosp 3, Resp Med, Beijing, Peoples R China

[46] Tongji Univ, Shanghai Pulm Hosp, Dept Resp Med, Shanghai, Peoples R China

[47] Clin Shaio, Bogota, Colombia

[48] Las Amer Clin, Medellin, Colombia

[49] Clin Univ Kinshasa, Kinshasa, DEM REP CONGO

[50] Interne Med, Dubrovnik, Croatia

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2019年 / 60卷

关键词：

Community acquired pneumonia; Oseltamivir; Viral pneumonia; Influenza; Viral swab; Testing; CRITICALLY-ILL PATIENTS; STAPHYLOCOCCUS-AUREUS; UNITED-STATES; INFLUENZA; INFECTION; VIRUSES; ADULTS; ETIOLOGY; OSELTAMIVIR; COINFECTION;

D O I：

10.1016/j.ejim.2018.10.020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

引用

页码：54 / 70

页数：17

共 47 条

[1] Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study [J].