Pak GITs to Aurora-A

被引：12

作者：

Cotteret, S ^{[1
]}

Chernoff, J ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

DEVELOPMENTAL CELL | 2005年 / 9卷 / 05期

关键词：

D O I：

10.1016/j.devcel.2005.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated kinases (Paks), previously best known for their role in cytoskeletal and transcriptional signaling pathways, also play an important role in centrosome dynamics via phosphorylation and activation of Aurora-A.

引用

收藏

页码：573 / 574

页数：2

相关论文

共 9 条

[1] Structural basis of Aurora-A activation by TPX2 at the mitotic spindle [J].

Bayliss, R ;

Sardon, T ;

Vernos, I ;

Conti, E .

MOLECULAR CELL, 2003, 12 (04) :851-862

[2] A novel mechanism for activation of the protein kinase aurora A [J].

Eyers, PA ;

Erikson, E ;

Chen, LG ;

Maller, JL .

CURRENT BIOLOGY, 2003, 13 (08) :691-697

[3] Aurora-A site specificity: a study with synthetic peptide substrates [J].

Ferrari, S ;

Marin, O ;

Pagano, MA ;

Meggio, F ;

Hess, D ;

El-Shemerly, M ;

Krystyniak, A ;

Pinna, LA .

BIOCHEMICAL JOURNAL, 2005, 390 :293-302

[4]

Goyal RK, 1999, MOL CELL BIOL, V19, P4379

[5] Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells [J].

Hirota, T ;

Kunitoku, N ;

Sasayama, T ;

Marumoto, T ;

Zhang, DW ;

Nitta, M ;

Hatakeyama, K ;

Saya, H .

CELL, 2003, 114 (05) :585-598

[6] The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome [J].

Pugacheva, EN ;

Golemis, EA .

NATURE CELL BIOLOGY, 2005, 7 (10) :937-U18

[7] Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells [J].

Vadlamudi, RK ;

Adam, L ;

Wang, RA ;

Mandal, M ;

Nguyen, D ;

Sahin, A ;

Chernoff, J ;

Hung, MC ;

Kumar, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) :36238-36244

[8] PAK and other Rho-associated kinases - effectors with surprisingly diverse mechanisms of regulation [J].

Zhao, ZS ;

Manser, E .

BIOCHEMICAL JOURNAL, 2005, 386 (02) :201-214

[9] The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A [J].

Zhao, ZS ;

Lim, JP ;

Ng, YW ;

Lim, L ;

Manser, E .

MOLECULAR CELL, 2005, 20 (02) :237-249