Pneumonitis complicating methotrexate therapy for pustular psoriasis

被引：11
作者：
Ameen, M
Taylor, DA
Williams, IP
Wells, AU
Barker, JNWN
机构：
[1] St Thomas Hosp, St Johns Inst Dermatol, London SE1 7EH, England
[2] Hemel Hempstead Gen Hosp, Dept Thorac Med, Hempstead, Herts, England
[3] Royal Brompton Natl Heart & Lung Hosp, London SW3 6NP, England
来源：
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2001年 / 15卷 / 03期
关键词：
methotrexate; pneumonitis; psoriasis;
D O I：
10.1046/j.1468-3083.2001.t01-1-00223.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report a patient with pustular psoriasis who developed interstitial pneumonitis after receiving weekly methotrexate (MTX) therapy at an average dose of 20 mg for 26 years. The patient responded dramatically to withdrawal of the drug and administration of corticosteroids. Pulmonary toxicity is a rare adverse effect of MTX therapy and is particularly uncommon in psoriatics. As interstitial pneumonitis is a potentially fatal but reversible complication, early respiratory symptoms even in patients on low-dose MTX treatment should be appropriately investigated.
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收藏
页码：247 / 249
页数：3
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