Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease

被引：17
作者：
Kishimoto, Yasushi [1 ]
Oku, Ikuko [1 ]
Nishigawa, Atsuko [1 ]
Nishimoto, Akiko [1 ]
Kirino, Yutaka [1 ]
机构：
[1] Tokushima Bunri Univ, Lab Neurobiophys, Kagawa Sch Pharmaceut Sci, Sanuki, Kagawa 7692196, Japan
来源：
NEUROSCIENCE LETTERS | 2012年 / 506卷 / 01期
关键词：
Aging; Alzheimer's disease; Eyeblink conditioning; Hippocampus; Trace conditioning; TRANSGENIC MICE; MEMORY DEFICITS; SYNAPTIC PLASTICITY; APP+PS1 MICE; A-BETA; CEREBELLUM; DELAY;
D O I：
10.1016/j.neulet.2011.10.071
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI = 500 ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：155 / 159
页数：5
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