Aging by epigenetics - A consequence of chromatin damage?

被引：106
作者：
Sedivy, John M. [1 ]
Banumathy, Gowrishankar [2 ]
Adams, Peter D. [2 ]
机构：
[1] Brown Univ, Div Biol & Med, Labs Mol Med, Providence, RI 02903 USA
[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
来源：
EXPERIMENTAL CELL RESEARCH | 2008年 / 314卷 / 09期
关键词：
epigenetics; chromatin; aging; longevity; cell senescence;
D O I：
10.1016/j.yexcr.2008.02.023
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. in some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：1909 / 1917
页数：9
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