Aging by epigenetics - A consequence of chromatin damage?

被引：106

作者：

Sedivy, John M. ^{[1
]}

Banumathy, Gowrishankar ^{[2
]}

Adams, Peter D. ^{[2
]}

机构：

[1] Brown Univ, Div Biol & Med, Labs Mol Med, Providence, RI 02903 USA

[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2008年 / 314卷 / 09期

关键词：

epigenetics; chromatin; aging; longevity; cell senescence;

D O I：

10.1016/j.yexcr.2008.02.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. in some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1909 / 1917

页数：9

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