Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer

被引：63

作者：

Eguchi, Taka ^{[1
]}

Prince, Thomas ^{[2
]}

Wegiel, Barbara ^{[3
]}

Calderwood, Stuart K. ^{[1
]}

机构：

[1] Harvard Univ, Dept Radiat Oncol, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02115 USA

[2] NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[3] Harvard Univ, Dept Surg, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2015年 / 116卷 / 10期

关键词：

MYELOID; ZINC; FINGER-1; CANCER; INVASION; SUMO; NUCLEAR BODY; SCAN DOMAIN; GENE-EXPRESSION; C-MYC; PML; PHOSPHORYLATION; BINDING; FAMILY; CELLS; BOX; OVEREXPRESSION;

D O I：

10.1002/jcb.25203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors. J. Cell. Biochem. 116: 2146-2154, 2015. (c) 2015 Wiley Periodicals, Inc.

引用

页码：2146 / 2154

页数：9

共 59 条

[1] A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells [J].

Anders, Lars ;

Ke, Nan ;

Hydbring, Per ;

Choi, Yoon J. ;

Widlund, Hans R. ;

Chick, Joel M. ;

Zhai, Huili ;

Vidal, Marc ;

Gygi, Stephen P. ;

Braun, Pascal ;

Sicinski, Piotr .

CANCER CELL, 2011, 20 (05) :620-634

[2] AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells [J].

Asiedu, M. K. ;

Beauchamp-Perez, F. D. ;

Ingle, J. N. ;

Behrens, M. D. ;

Radisky, D. C. ;

Knutson, K. L. .

ONCOGENE, 2014, 33 (10) :1316-1324

[3] Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies [J].

Bernardi, Rosa ;

Pandolfi, Pier Paolo .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (12) :1006-1016

[4] SUMOylation in carcinogenesis [J].

Bettermann, Kira ;

Benesch, Martin ;

Weis, Serge ;

Haybaeck, Johannes .

CANCER LETTERS, 2012, 316 (02) :113-125

[5] KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies [J].

Briers, Stephanie ;

Crawford, Catherine ;

Bickmore, Wendy A. ;

Sutherland, Heidi G. .

JOURNAL OF CELL SCIENCE, 2009, 122 (07) :937-946

[6] TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release [J].

Bunch, Heeyoun ;

Zheng, Xiaofeng ;

Burkholder, Adam ;

Dillon, Simon T. ;

Motola, Shmulik ;

Birrane, Gabriel ;

Ebmeier, Christopher C. ;

Levine, Stuart ;

Fargo, David ;

Hu, Guang ;

Taatjes, Dylan J. ;

Calderwood, Stuart K. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (10) :876-883

[7]

Calderwood Stuart K, 2015, Subcell Biochem, V78, P103, DOI 10.1007/978-3-319-11731-7_5

[8] Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1 [J].

Cappadocia, Laurent ;

Mascle, Xavier H. ;

Bourdeau, Veronique ;

Tremblay-Belzile, Samuel ;

Chaker-Margot, Malik ;

Lussier-Price, Mathieu ;

Wada, Junya ;

Sakaguchi, Kazuyasu ;

Aubry, Muriel ;

Ferbeyre, Gerardo ;

Omichinski, James G. .

STRUCTURE, 2015, 23 (01) :126-138

[9] The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data [J].

Cerami, Ethan ;

Gao, Jianjiong ;

Dogrusoz, Ugur ;

Gross, Benjamin E. ;

Sumer, Selcuk Onur ;

Aksoy, Buelent Arman ;

Jacobsen, Anders ;

Byrne, Caitlin J. ;

Heuer, Michael L. ;

Larsson, Erik ;

Antipin, Yevgeniy ;

Reva, Boris ;

Goldberg, Arthur P. ;

Sander, Chris ;

Schultz, Nikolaus .

CANCER DISCOVERY, 2012, 2 (05) :401-404

[10] Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Para log-Selective Binding and Apoptosis Modulation [J].

Chang, Che-Chang ;

Naik, Mandar T. ;

Huang, Yen-Sung ;

Jeng, Jen-Chong ;

Liao, Pei-Hsin ;

Kuo, Hong-Yi ;

Ho, Chun-Chen ;

Hsieh, Yung-Lin ;

Lin, Chiou-Hong ;

Huang, Nai-Jia ;

Naik, Nandita M. ;

Kung, Camy C-H. ;

Lin, Shu-Yu ;

Chen, Ruey-Hwa ;

Chang, Kun-Sang ;

Huang, Tai-Huang ;

Shih, Hsiu-Ming .

MOLECULAR CELL, 2011, 42 (01) :62-74

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