(11aS)-7-Bromo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione

被引：1

作者：

Ma, Chao ^{[2
]}

Wang, Zhen-Zhong ^{[1
]}

Pan, Li ^{[2
]}

Tian, Yu ^{[2
]}

Xiao, Wei ^{[1
]}

机构：

[1] Jiangsu Kanion Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2012年 / 68卷

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

PYRROLO<2,1-C><1,4>BENZODIAZEPINES; DC-81;

D O I：

10.1107/S1600536811052962

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title compound, C12H11BrN2O2, was prepared by an intra-cyclization reaction of (S)-1-(5-bromo-2-nitrobenzyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester in the presence of EtOH/Fe. The five-membered pyrrolidinone ring adopts an approximate envelope conformation, while the seven-membered diazepanone ring displays a twisted boat conformation. Intermolecular classical N-H center dot center dot center dot O hydrogen bonds and weak C-H center dot center dot center dot O interactions help to stabilize the crystal structure.

引用

页数：9

共 10 条

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