Biomarkers in Solid Organ Transplantation

被引:9
作者
Choi, John [1 ]
Bano, Albana [1 ]
Azzi, Jamil [1 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Div Renal, Transplantat Res Ctr, 221 Longwood Ave, Boston, MA 02115 USA
关键词
Transplant; Biomarker; Allograft; Rejection; Transplant immunology; QUALITY-OF-LIFE; CELL-FREE DNA; RISK-STRATIFYING BIOMARKER; RENAL-ALLOGRAFT REJECTION; B-CELLS; KIDNEY-TRANSPLANTATION; HLA ANTIBODIES; LIVER-TRANSPLANTATION; CHEMOKINE RECEPTORS; IMMUNE-RESPONSE;
D O I
10.1016/j.cll.2018.11.003
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
After more than 6 decades of clinical practice, the transplant community continues to research noninvasive biomarkers of solid organ injury to help improve patient care. In this review, we discuss the clinical usefulness of selective biomarkers and how they are processed at the laboratory. In addition, we organize these biomarkers based on specific aims and introduce innovative markers currently under investigation.
引用
收藏
页码:73 / +
页数:14
相关论文
共 110 条
[1]   Applying rigor and reproducibility standards to assay donor-derived cell-free DNA as a non-invasive method for detection of acute rejection and graft injury after heart transplantation [J].
Agbor-Enoh, Sean ;
Tunc, Ilker ;
De Vlaminck, Iwijn ;
Fideli, Ulgen ;
Davis, Andrew ;
Cuttin, Karen ;
Bhatti, Kenneth ;
Marishta, Argit ;
Solomon, Michael A. ;
Jackson, Annette ;
Graninger, Grace ;
Harper, Bonnie ;
Luikart, Helen ;
Wylie, Jennifer ;
Wang, Xujing ;
Berry, Gerald ;
Marboe, Charles ;
Khush, Kiran ;
Zhu, Jun ;
Valantine, Hannah .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2017, 36 (09) :1004-1012
[2]   Angiotensin Antibodies and Focal Segmental Glomerulosclerosis [J].
Alachkar, Nada ;
Gupta, Gaurav ;
Montgomery, Robert A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (10) :971-973
[4]   Standardization and Cross Validation of Alloreactive IFN ELISPOT Assays Within the Clinical Trials in Organ Transplantation Consortium [J].
Ashoor, I. ;
Najafian, N. ;
Korin, Y. ;
Reed, E. F. ;
Mohanakumar, T. ;
Ikle, D. ;
Heeger, P. S. ;
Lin, M. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (07) :1871-1879
[5]   Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].
Atkinson, AJ ;
Colburn, WA ;
DeGruttola, VG ;
DeMets, DL ;
Downing, GJ ;
Hoth, DF ;
Oates, JA ;
Peck, CC ;
Schooley, RT ;
Spilker, BA ;
Woodcock, J ;
Zeger, SL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95
[6]   Kidney Intragraft Donor-Specific Antibodies as Determinant of Antibody-Mediated Lesions and Poor Graft Outcome [J].
Bachelet, T. ;
Couzi, L. ;
Lepreux, S. ;
Legeret, M. ;
Pariscoat, G. ;
Guidicelli, G. ;
Merville, P. ;
Taupin, J-L .
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (11) :2855-2864
[7]   Donor-Derived Cell-Free DNA Is a Novel Universal Biomarker for Allograft Rejection in Solid Organ Transplantation [J].
Beck, J. ;
Oellerich, M. ;
Schulz, U. ;
Schauerte, V. ;
Reinhard, L. ;
Fuchs, U. ;
Knabbe, C. ;
Zittermann, A. ;
Olbricht, C. ;
Gummert, J. F. ;
Shipkova, M. ;
Birschmann, I. ;
Wieland, E. ;
Schuetz, E. .
TRANSPLANTATION PROCEEDINGS, 2015, 47 (08) :2400-2403
[8]  
BRASILE L, 1986, SURGERY, V99, P637
[9]   Health-related quality of life after liver transplantation: A meta-analysis [J].
Bravata, DM ;
Olkin, I ;
Barnato, AE ;
Keeffe, EB ;
Owens, DK .
LIVER TRANSPLANTATION AND SURGERY, 1999, 5 (04) :318-331
[10]  
BUNZEL B, 1991, J HEART LUNG TRANSPL, V10, P455