Cancer stem cells in glioblastoma

被引:1245
作者
Lathia, Justin D. [1 ,2 ]
Mack, Stephen C. [3 ]
Mulkearns-Hubert, Erin E. [1 ]
Valentim, Claudia L. L. [3 ]
Rich, Jeremy N. [2 ,3 ]
机构
[1] Cleveland Clin, Lerner Res Inst, Department Cellular & Mol Med, Cleveland, OH 44195 USA
[2] Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin, Dept Mol Med, Cleveland, OH 44195 USA
[3] Cleveland Clin, Lerner Res Inst, Dept Stem Cell Biol & Regenerat Med, Cleveland, OH 44195 USA
基金
加拿大健康研究院; 美国国家卫生研究院;
关键词
brain tumor; cancer stem cell; glioblastoma; glioma; stem cell; tumor-initiating cell; TUMOR-INITIATING CELLS; GENE-EXPRESSION; SELF-RENEWAL; TGF-BETA; MAINTAINS TUMORIGENICITY; SIDE POPULATION; EMBRYONIC STEM; GLIOMA GROWTH; RNAI SCREEN; PATHWAY;
D O I
10.1101/gad.261982.115
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units; rather, they function within an ecological system, both actively remodeling the microenvironment and receiving critical maintenance cues from their niches. To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial.
引用
收藏
页码:1203 / 1217
页数:15
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