Duration of SARS-CoV-2 RNA shedding and factors associated with prolonged viral shedding in patients with COVID-19

被引：65

作者：

Li, Tong-Zeng ^{[1
]}

Cao, Zhen-Huan ^{[1
]}

Chen, Yu ^{[2
]}

Cai, Miao-Tian ^{[1
]}

Zhang, Long-Yu ^{[1
]}

Xu, Hui ^{[1
]}

Zhang, Jia-Ying ^{[1
]}

Ma, Chun-Hua ^{[1
]}

Liu, Yang ^{[1
]}

Gao, Li-Juan ^{[1
]}

Duan, Zhong-Hui ^{[1
]}

Mou, Dan-Lei ^{[1
]}

Liang, Lian-Chun ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Youan Hosp, Dept Infect Dis, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Youan Hosp, Difficult & Complicated Liver Dis & Artificial Li, Beijing, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 01期

关键词：

coronavirus; COVID-19; duration of viral shedding; CORTICOSTEROID TREATMENT; SARS;

D O I：

10.1002/jmv.26280

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 RNA shedding in patients with coronavirus disease 2019 (COVID-19). A retrospective cohort of COVID-19 patients admitted to a designated hospital in Beijing was analyzed to study the factors affecting the duration of viral shedding. The median duration of viral shedding was 11 days (IQR, 8-14.3 days) as measured from illness onset. Univariate regression analysis showed that disease severity, corticosteroid therapy, fever (temperature>38.5 degrees C), and time from onset to hospitalization were associated with prolonged duration of viral shedding (P < .05). Multivariate regression analysis showed that fever (temperature>38.5 degrees C) (OR, 5.1, 95%CI: 1.5-18.1), corticosteroid therapy (OR, 6.3, 95%CI: 1.5-27.8), and time from onset to hospitalization (OR, 1.8, 95%CI: 1.19-2.7) were associated with increased odds of prolonged duration of viral shedding. Corticosteroid treatment, fever (temperature>38.5 degrees C), and longer time from onset to hospitalization were associated with prolonged viral shedding in COVID-19 patients.

引用

页码：506 / 512

页数：7

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