A pilot study on the nutraceutical properties of the Citrus hybrid Tacle® as a dietary source of polyphenols for supplementation in metabolic disorders

被引：26

作者：

Casacchia, Teresa ^{[1
]}

Occhiuzzi, Maria Antonietta ^{[1
]}

Grande, Fedora ^{[1
]}

Rizzuti, Bruno ^{[2
,3
]}

Granieri, Maria Concetta ^{[4
]}

Rocca, Carmine ^{[4
]}

Gattuso, Alfonsina ^{[4
]}

Garofalo, Antonio ^{[1
]}

Angelone, Tommaso ^{[4
]}

Statti, Giancarlo ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Via P Bucci, I-87036 Arcavacata Di Rende, CS, Italy

[2] Univ Calabria, Dept Phys, Licryl UOS Cosenza, CNR NANOTEC, Via P Bucci, I-87036 Arcavacata Di Rende, CS, Italy

[3] Univ Calabria, Dept Phys, CEMIF Cal, Via P Bucci, I-87036 Arcavacata Di Rende, CS, Italy

[4] Univ Calabria, Dept Biol Ecol & Earth Sci, Via P Bucci, I-87036 Arcavacata Di Rende, CS, Italy

来源：

JOURNAL OF FUNCTIONAL FOODS | 2019年 / 52卷

关键词：

Glycosides; Human pancreatic amylase; Human pancreatic lipase; Anthropometric parameters; Molecular docking; SINENSIS L. OSBECK; ANTIOXIDANT ACTIVITY; GLUCOSIDASE ACTIVITY; GLUCOSYL HESPERIDIN; SMALL-INTESTINE; BETA-OXIDATION; ALPHA-AMYLASE; PEEL EXTRACT; IN-VITRO; OBESITY;

D O I：

10.1016/j.jff.2018.11.030

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Tacle (R) is a citrus variety obtained from the crossbreeding of Clementine and Tarocco tetraploids. This new fruit recently gained an increasing interest due to its commercial value and nutraceutical properties. A high content in polyphenols confers to its extracts a protective activity against oxidative agents involved in several degenerative disorders. In this study, we investigated the antioxidant potential of Tacle and its inhibitory activity against human amilase and lipase in vitro. These particular features could be ascribed to the relevant content in naringin and hesperidin glycosides and the corresponding aglycones have been in silico demonstrated able to bind the active site of both enzymes. The overall results showed an enhanced nutraceutical profile of Tacle with respect to citrus parents, suggesting that a dietary enrichment with its extracts could be useful in the complementary treatment of metabolic disorders such as obesity and diabetes, as assessed by in vivo experiments on rats.

引用

页码：370 / 381

页数：12

共 78 条

[1] Hesperidin Produces Cardioprotective Activity via PPAR-γ Pathway in Ischemic Heart Disease Model in Diabetic Rats [J].