Preparation of Nano-fibrous poly(L-lactic acid) scaffold with hierarchical pores

In this study, a nano-fibrous PLLA scaffold with hierarchical pore was sucessfully fabricated using combined TIPS and particle leaching method. The scaffold had a nano-fibrous PLLA matrix (fiber size 100-800 nm), an interconnective hierarchical pores (1.0- 425 mu m), high porosity (>96%). The compressive modulus of scaffold with different pore size was between 0.16 MPa to 0.2 Mpa and it decreased with the increased salt size embedded in. The new nano composite scaffold is potentially a very promising scaffold for tissue engineering.