Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films

被引：25

作者：

Das, Aritra ^{[1
]}

Bhattacharyya, Srirupa ^{[2
]}

Uppaluri, Ramagopal ^{[1
]}

Das, Chandan ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem Engn, Gauhati 781039, Assam, India

[2] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Gauhati 781039, Assam, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 155卷

关键词：

Composite; Film; Swelling index; Degradability; Wound dressing; CITRIC-ACID; HYDROGEL;

D O I：

10.1016/j.ijbiomac.2020.03.185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films. Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies. The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data. Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：260 / 272

页数：13