Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

被引：52

作者：

Chen, Zhe ^{[1
]}

Rank, Elisabet ^{[1
]}

Meiburger, Kristen M. ^{[2
]}

Sinz, Christoph ^{[3
]}

Hodul, Andreas ^{[1
]}

Zhang, Edward ^{[4
]}

Hoover, Erich ^{[5
]}

Minneman, Micheal ^{[5
]}

Ensher, Jason ^{[5
]}

Beard, Paul C. ^{[4
]}

Kittler, Harald ^{[3
]}

Leitgeb, Rainer A. ^{[1
]}

Drexler, Wolfgang ^{[1
]}

Liu, Mengyang ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Med Phys & Biomed Engn, Wahringer Gurtel 18-20,AKH 4L, A-1090 Vienna, Austria

[2] Politecn Torino, Biolab, Dipartimento Elettron & Telecomunicaz, Corso Duca Abruzzi 24, I-10129 Turin, Italy

[3] Med Univ Vienna, Dept Dermatol, Wahringer Gurtel 18-20,AKH 7J, A-1090 Vienna, Austria

[4] UCL, Dept Med Phys & Biomed Engn, Gower St, London WC1E 6BT, England

[5] Insight Photon Solut Inc, 2650 Crescent Dr,201, Lafayette, CO 80026 USA

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

奥地利科学基金会;

关键词：

OPTOACOUSTIC MESOSCOPY; OCT ANGIOGRAPHY; VASCULATURE; MICROSCOPY; QUANTIFICATION; ANGIOGENESIS; FREQUENCY;

D O I：

10.1038/s41598-017-18331-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cutaneous vasculature is involved in many diseases. Current clinical examination techniques, however, cannot resolve the human vasculature with all plexus in a non-invasive manner. By combining an optical coherence tomography system with angiography extension and an all optical photoacoustic tomography system, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively. With a customized imaging unit that permits access to various parts of patients' bodies, we applied our multimodality imaging system to investigate several different types of skin conditions. Quantitative vascular analysis is given for each of the dermatological conditions to show the potential diagnostic value of our system in non-invasive examination of diseases and physiological processes. Improved performance of our system over its previous generation is also demonstrated with an updated characterization.

引用

页数：11

共 42 条

[1] Broadband mesoscopic optoacoustic tomography reveals skin layers
Aguirre, Juan
Schwarz, Mathias
Soliman, Dominik
Buehler, Andreas
Omar, Murad
Ntziachristos, Vasilis
[J]. OPTICS LETTERS, 2014, 39 (21) : 6297 - 6300
[2] Acoustic Wave Field Reconstruction From Compressed Measurements With Application in Photoacoustic Tomography
Betcke, Marta M.
Cox, Ben T.
Nam Huynh
Zhang, Edward Z.
Beard, Paul C.
Arridge, Simon R.
[J]. IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING, 2017, 3 (04): : 710 - 721
[3] Measuring tortuosity of the intracerebral vasculature from MRA images
Bullitt, E
Gerig, G
Pizer, SM
Lin, WL
Aylward, SR
[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING, 2003, 22 (09) : 1163 - 1171
[4] Phase-stable swept source OCT angiography in human skin using an akinetic source
Chen, Zhe
Liu, Mengyang
Minneman, Michael
Ginner, Laurin
Hoover, Erich
Sattmann, Harald
Bonesi, Marco
Drexler, Wolfgang
Leitgeb, Rainer A.
[J]. BIOMEDICAL OPTICS EXPRESS, 2016, 7 (08): : 3032 - 3048
[5] CANCER Inflammation lights the way to metastasis
Coffelt, Seth B.
de Visser, Karin E.
[J]. NATURE, 2014, 507 (7490) : 48 - 49
[6] Angiogenesis imaging - ultrasound
Cosgrove, D
[J]. BRITISH JOURNAL OF RADIOLOGY, 2003, 76 : S43 - S49
[7] In vivo micro-angiography by means of speckle-variance optical coherence tomography (SV-OCT) is able to detect microscopic vascular changes in naevus to melanoma transition
De Carvalho, N.
Ciardo, S.
Cesinaro, A. M.
Jemec, G. B. E.
Ulrich, M.
Welzel, J.
Holmes, J.
Pellacani, G.
[J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2016, 30 (10) : E67 - E68
[8] Drexler W., 2015, Optical Coherence Tomography: Technology and Applications, V2
[9] Frangi AF, 1998, LECT NOTES COMPUT SC, V1496, P130, DOI 10.1007/BFb0056195
[10] The dermal arteries of the human thumb pad
Geyer, S. H.
Noehammer, M. M.
Tinhofer, I. E.
Weninger, W. J.
[J]. JOURNAL OF ANATOMY, 2013, 223 (06) : 603 - 609

← 1 2 3 4 5 →