Synthesis of 4-Oxoindeno[1,2-b]pyrroles through Copper-Catalyzed Tandem Reactions of 1-(2-Haloaryl)enones with Isocyanides

被引：7

作者：

Zhou, Fengtao

Fu, Liangbing

Wie, Jiajia

Ding, Ke

Cai, Qian ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou Inst Biomed, Guangzhou 510530, Guangdong, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2011年 / 18期

关键词：

copper-catalyzed; isocyanide; enones; pyrroles; ASYMMETRIC ALDOL REACTION; OLIGOSUBSTITUTED PYRROLES; CROSS-CYCLOADDITION; CARBONYL-COMPOUNDS; ISOCYANOACETATE; ALDEHYDES; COMPLEX; DERIVATIVES; ACETYLENES; AGONISTS;

D O I：

10.1055/s-0030-1260171

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed tandem reactions of 1-(2-haloaryl)enones with isocyanides for the synthesis of 4-oxoindeno[1,2-b]pyrroles are described. Highly reactive cyclic organocopper intermediates are generated in the copper-catalyzed [3+2]-cycloaddition reactions of isocyanides to double or triple bonds. Successful intramolecular trapping of the organocopper intermediates led to the efficient formation of 4-oxoindeno[1,2-b]pyrroles.

引用

页码：3037 / 3044

页数：8

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