Synthesis of 4-Oxoindeno[1,2-b]pyrroles through Copper-Catalyzed Tandem Reactions of 1-(2-Haloaryl)enones with Isocyanides

被引：7
|
作者：
Zhou, Fengtao
Fu, Liangbing
Wie, Jiajia
Ding, Ke
Cai, Qian [1 ]
机构：
[1] Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou Inst Biomed, Guangzhou 510530, Guangdong, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2011年 / 18期
关键词：
copper-catalyzed; isocyanide; enones; pyrroles; ASYMMETRIC ALDOL REACTION; OLIGOSUBSTITUTED PYRROLES; CROSS-CYCLOADDITION; CARBONYL-COMPOUNDS; ISOCYANOACETATE; ALDEHYDES; COMPLEX; DERIVATIVES; ACETYLENES; AGONISTS;
D O I：
10.1055/s-0030-1260171
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed tandem reactions of 1-(2-haloaryl)enones with isocyanides for the synthesis of 4-oxoindeno[1,2-b]pyrroles are described. Highly reactive cyclic organocopper intermediates are generated in the copper-catalyzed [3+2]-cycloaddition reactions of isocyanides to double or triple bonds. Successful intramolecular trapping of the organocopper intermediates led to the efficient formation of 4-oxoindeno[1,2-b]pyrroles.
引用
收藏
页码：3037 / 3044
页数：8
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