Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

被引：9

作者：

Ruan, Yongsheng ^{[1
]}

Chen, Libai ^{[1
]}

Xie, Danfeng ^{[1
]}

Luo, Tingting ^{[1
]}

Xu, Yiqi ^{[1
]}

Ye, Tao ^{[2
]}

Chen, Xiaona ^{[1
]}

Feng, Xiaoqin ^{[1
]}

Wu, Xuedong ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Pediat, Guangzhou, Peoples R China

[2] Southern Med Univ, Affiliated Baoan Hosp Shenzhen, Dept Endocrinol, Shenzhen, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

关键词：

cell adhesion-mediated drug resistance; endocrine-related cancers; tumor microenvironment; cell adhesion molecules; chemoresistance; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; E-CADHERIN; OVARIAN-CANCER; PANCREATIC-CANCER; STEM-CELL; P-SELECTIN; TUMOR PROGRESSION; DRUG-RESISTANCE; PHENOTYPIC HETEROGENEITY;

D O I：

10.3389/fendo.2022.865436

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.

引用

页数：16

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