Long-Term Outcomes Using Electron IOERT APBI for Early Stage Breast Cancer: The Verona University Hospital Experience

被引:4
作者
Cernusco, Nunzia Luna Valentina [1 ]
Del Bianco, Paola [2 ]
Romano, Mario [1 ]
Muraglia, Alessandro [1 ]
Rossi, Gabriella [1 ]
Giri, Maria Grazia [3 ]
Guariglia, Stefania [3 ]
Lombardi, Davide [4 ]
Pellini, Francesca [4 ]
Cavedon, Carlo [3 ]
Pollini, Giovanni Paolo [4 ]
Mazzarotto, Renzo [1 ]
机构
[1] Verona Univ Hosp, Radiat Therapy Unit, Piazzale Stefani, Verona, Italy
[2] Veneto Inst Oncol IOV IRCCS, Clin Res Unit, Padua, Italy
[3] Verona Univ Hosp, Med Phys Unit, Verona, Italy
[4] Verona Univ Hosp, Breast Surg Unit, Verona, Italy
关键词
APBI; Early stage Breast cancer; Radiation Therapy; IOERT; Breast Conserving Therapy; CONSERVING SURGERY; INTRAOPERATIVE RADIOTHERAPY; RADIATION-THERAPY; IN-SITU; IRRADIATION; PHASE-3; RECURRENCE; CARCINOMA; SURVIVAL; ELIOT;
D O I
10.1016/j.clbc.2021.05.015
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have evaluate long-term outcome of intraoperative electron accelerated partial breast radiotherapy (IOERT APBI) on 295 patients suitable for breast-conserving therapy. With a median follow-up of 7.1 years (95% CI, 6.5;7.4) 6 women (2.0%) experienced a true local recurrence. Our trial suggests that, in highly selected early stage breast cancers, a single-dose IOERT can be safely delivered with excellent results and very low long-term recurrence rates. Methods and Materials: From July 2006 to December 2015, 295 patients suitable for breast-conserving therapy entered a single-arm phase II study and were treated with IOERT as radical treatment. Inclusion criter ia were age >50, postmenopausal status, cT1N0M0 stage, grade G1-G2, positive estrogen receptor status; unicentric and unifocal disease, histologically proven invasive ductal carcinoma no previous breast irradiation, good performance status. Results: With a median follow-up of 7.1 years (95% CI, 6.5;7.4) 6 women (2.0%) experienced a true local recurrence (reappearance of the tumour in the same quadrant). Five-year overall survival and local recurrence-free survival were 96% (95% CI, 92.9;97.8) and 94.9% (95% CI, 91.6;97.0) respectively. Conclusion: Our trial suggests that, in highly selected early stage breast cancers, a single-dose IOERT can be safely delivered with excellent results and very low long-term recurrence rates. (C) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码:E167 / E172
页数:6
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