A novel function for fibroblast growth factor 21: stimulation of NADPH oxidase-dependent ROS generation

被引：8

作者：

Wang, Wen-fei ^{[1
,2
]}

Ma, Lei ^{[1
,2
]}

Liu, Ming-yao ^{[1
,2
]}

Zhao, Ting-ting ^{[2
,3
]}

Zhang, Tong ^{[1
]}

Yang, Yong-bi ^{[1
,2
]}

Cao, Hong-xue ^{[1
,2
]}

Han, Xiao-hui ^{[1
]}

Li, De-shan ^{[1
,2
]}

机构：

[1] Northeast Agr Univ, Coll Life Sci, Harbin 150030, Peoples R China

[2] Northeast Agr Univ, Key Lab Agr Biol Funct Gene, Harbin 150030, Peoples R China

[3] Harbin 242 Hosp, Harbin 150066, Peoples R China

来源：

ENDOCRINE | 2015年 / 49卷 / 02期

关键词：

Neutrophils; Monocytes; Oxidative burst; Innate immunity; FGF-21; OXIDATIVE STRESS; ACTIVATION; CELLS; DIFFERENTIATION; PATHWAY; ROLES; FGF21; BURST; PTEN;

D O I：

10.1007/s12020-014-0502-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factor 21 (FGF-21) is a major paracrine and endocrine regulator of metabolic homeostasis. Here we demonstrate that FGF-21 is also a potent mediator of innate immunity. Double-staining flow cytometry identified neutrophils and monocytes as the main sources of FGF-21 among circulating leukocytes. Functional assays showed that FGF-21 stimulates phagocytosis and production of reactive oxygen species in neutrophil-like HL-60 cells and monocytic THP-1 cells. The mechanism of action of FGF-21 was observed to involve FGF receptor activation, signal transduction through the PI3K/Akt pathway, and stimulation of NADPH oxidase activity. This study indicates that FGF-21 could be an attractive target for the management of inflammatory disorders.

引用

页码：385 / 395

页数：11

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