An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems

被引：71

作者：

Jug, Mario ^{[1
]}

Hafner, Anita ^{[1
]}

Lovric, Jasmina ^{[1
]}

Kregar, Maja Lusina ^{[2
]}

Pepic, Ivan ^{[1
]}

Vanic, Zeljka ^{[1
]}

Cetina-Cizmek, Biserka ^{[2
]}

Filipovic-Grcic, Jelena ^{[1
]}

机构：

[1] Univ Zagreb, Fac Pharm & Biochem, Dept Pharmaceut Technol, A Kovacica 1, Zagreb 10000, Croatia

[2] PLIVA Croatia Ltd, Prilaz Baruna Filipovica 25, Zagreb 10000, Croatia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2018年 / 147卷

关键词：

In vitro release; Ocular drug delivery system; Nasal drug delivery system; Oromucosal drug delivery system; Vaginal drug delivery system; Rectal drug delivery systems; NANOSTRUCTURED LIPID CARRIERS; TOPICAL VAGINAL THERAPY; FILMS CURRENT STATUS; BUCCAL DELIVERY; OCULAR DELIVERY; INTRANASAL DELIVERY; SITU GEL; EX-VIVO; NASAL DELIVERY; CHITOSAN NANOPARTICLES;

D O I：

10.1016/j.jpba.2017.06.072

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single test system which would be suitable for release testing of such complex dosage forms. This article is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：350 / 366

页数：17

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