Determination of Dimethylsulphoxide as Residual Solvent by Static Headspace Gas Chromatography

被引：0

作者：

Zheng Chao ^{[1
]}

Wang Bo-Chu ^{[1
]}

Zhu Lian-Cai ^{[1
]}

机构：

[1] Chongqing Univ, Coll Bioengn, Chongqing 400044, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2011年 / 39卷 / 07期

关键词：

Static headspace; Gas chromatography; Residual solvent; Dimethyl sulphoxide;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive, precise static headspace gas chromatography method coupled with flame ionization detection was developed for the analysis of residual dimethyl sulphoxide (DMSO) in drugs. Liquid paraffin oil was used as dilute solvent, liquid volume in the vial and GC parameters such as autosampler injection time, headspace pressurize time, equilibration temperature, equilibration time and oven temperature program were optimized to yield the highest sensitivity. Optimum value of GC parameters such as equilibration temperature, equilibration time, headspace pressurize time, autosampler injection time were 160 degrees C, 15 min, 1. 0 min, 0. 08 min respectively. Limits of detection (LOD) and quantitation (LOQ) were determined to be 1 and 3 mu g/g, respectively. Linear regression equation in the range of 25-300 mu g/g was y=215. 49x-828. 94 with R-2 of 0. 9991. The method was successfully used to analyze residual DMSO in drug coating materials Kollicoat (R) IR.

引用

页码：1117 / 1120

页数：4

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