Paraneoplastic neurological degenerations: Keys to tumour immunity

被引：128

作者：

Albert, ML ^{[1
]}

Darnell, RB ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1255

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Paraneoplastic neurological degenerations (PNDs) are neurological disorders that develop in patients with cancer. PNDs are triggered by an effective antitumour immune response against neuronal antigens that are expressed in cancer cells, which subsequently develops into autoimmune neurodegenerative disease. Studying patients with PND has offered the opportunity to gain unique insights into mechanisms of tumour immunity and has provided the potential to apply this knowledge to patients with cancer in general.

引用

页码：36 / 44

页数：9

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