The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches

被引：210

作者：

Xu, Dongwei ^{[1
]}

Xu, Min ^{[1
]}

Jeong, Seogsong ^{[1
]}

Qian, Yihan ^{[2
]}

Wu, Hailong ^{[3
]}

Xia, Qiang ^{[1
]}

Kong, Xiaoni ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Liver Surg, Shanghai, Peoples R China

[2] Fudan Univ, Sch Pharm, Shanghai, Peoples R China

[3] Shanghai Univ Med & Hlth Sci, Collaborat Res Ctr, Shanghai Key Lab Mol Imaging, Shanghai, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Nrf2; oxidative stress; cytoprotective genes; acute liver injury; viral hepatitis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatocellular carcinoma; HEPATOCELLULAR-CARCINOMA CELLS; C VIRUS-REPLICATION; OXIDATIVE STRESS; ANTIOXIDANT RESPONSE; HEME OXYGENASE-1; TRANSCRIPTION FACTOR; CDDO-IMIDAZOLIDE; ACTIVATING NRF2; FACTOR-2; NRF2; PROTECTS;

D O I：

10.3389/fphar.2018.01428

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxidative stress and inflammation are the most important pathogenic events in the development and progression of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) is the master regulator of the cellular protection via induction of anti-inflammatory, antioxidant, and cyto-protective genes expression. Multiple studies have shown that activation or suppression of this transcriptional factor significantly affect progression of liver diseases. Comprehensive understanding the roles of Nrf2 activation/expression and the outcomes of its activators/inhibitors are indispensable for defining the mechanisms and therapeutic strategies against liver diseases. In this current review, we discussed recent advances in the function and principal mechanisms by regulating Nrf2 in liver diseases, including acute liver failure, hepatic ischemia-reperfusion injury (IRI), alcoholic liver disease (ALD), viral hepatitis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC).

引用

页数：7

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