TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes

被引：21

作者：

Bernard, Elsa ^{[1
]}

Nannya, Yasuhito ^{[2
]}

Yoshizato, Tetsuichi ^{[3
]}

Hasserjian, Robert P. ^{[4
]}

Saiki, Ryunosuke ^{[5
]}

Shiozawa, Yusuke ^{[6
]}

Devlin, Sean M. ^{[7
]}

Tuechler, Heinz ^{[8
]}

Sarian, Araxe ^{[1
]}

Malcovati, Luca ^{[9
]}

Sole, Francesc ^{[10
]}

Haase, Detlef ^{[11
,12
]}

Creignou, Maria ^{[13
]}

Levine, Max ^{[1
]}

Germing, Ulrich ^{[14
]}

Cargo, Catherine ^{[15
]}

Zhang, Yanming ^{[16
]}

Medina, Juan ^{[1
]}

Ossa, Juan E. Arango ^{[1
]}

Schanz, Julie ^{[11
,12
]}

van de Loosdrecht, Arjan ^{[17
]}

Jadersten, Martin ^{[18
]}

Bennett, John M. ^{[19
]}

Tobiasson, Magnus ^{[20
]}

Kosmider, Olivier ^{[21
]}

Follo, Matilde Y. ^{[22
]}

Thol, Felicitas ^{[23
]}

Pinheiro, Ronald F. ^{[24
]}

Santini, Valeria ^{[25
]}

Kotsianidis, Ioannis ^{[26
]}

Boultwood, Jacqueline ^{[27
]}

Santos, Fabio P. S. ^{[28
]}

Kasahara, Senji ^{[29
]}

Ishikawa, Takayuki ^{[30
]}

Tsurumi, Hisashi ^{[31
]}

Takaori-Kondo, Akifumi ^{[32
]}

Kiguchi, Toru ^{[33
]}

Polprasert, Chantana ^{[34
]}

Klimek, Virginia M. ^{[35
]}

Savona, Michael R. ^{[36
,37
]}

Belickova, Monika ^{[38
]}

Ganster, Christina ^{[12
]}

Ades, Lionel ^{[39
]}

Della Porta, Matteo Giovanni ^{[40
,41
]}

Smith, Alexandra ^{[42
]}

Werner, Yesenia ^{[1
]}

Patel, Minal A. ^{[43
]}

Viale, Agnes ^{[1
]}

Vanness, Katelynd ^{[1
]}

Neuberg, Donna S. ^{[44
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[2] Kyoto Univ, Kyoto, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Kyoto, Japan

[4] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[5] Kyoto Univ, Kyoto, Japan

[6] Kyoto Univ, Dept Pathol & Tumor Biol, Kyoto, Japan

[7] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[8] Hanusch Hosp, Boltzmann Inst Leukemia Res, Vienna, Austria

[9] Univ Pavia, Dept Mol Med & Hematol Oncol, Med Sch, Piazzale Golgi 2, Pavia, Italy

[10] Josep Carreras Res Inst IJC, Badalona, Spain

[11] Univ Med Ctr Gottingen, Clin Hematol, Gottingen, Germany

[12] Univ Med Ctr Gottingen, Clin Med Oncol, Gottingen, Germany

[13] Karolinska Univ Hosp, Stockholm, Sweden

[14] Heinrich Heine Univ, Dept Hematol Oncol & Clin Immunol, Dusseldorf, Germany

[15] St James Univ Hosp, Haematol Malignancy Diagnost Serv, Leeds, W Yorkshire, England

[16] Mem Sloan Kettering Canc Ctr, Dept Pathol, Chicago, IL USA

[17] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands

[18] Karolinska Inst, Hematol, Stockholm, Sweden

[19] Univ Rochester, Rochester, NY USA

[20] Karolinska Univ, Karolinska Inst, Dept Med, Ctr Hematol & Regenerat Med,Hosp Huddinge, Stockholm, Sweden

[21] Hop Cochin, AP HP, Lab Hematol, Paris, France

[22] Univ Bologna, Biomed & Neuromotor Sci, Bologna, Italy

[23] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany

[24] Univ Fed Ceara, Drug Res & Dev Ctr, Canc Cytogen Lab, Fortaleza, Ceara, Brazil

[25] Univ Florence, AOU Careggi, MDS Unit, Florence, Italy

[26] Democritus Univ Thrace, Dept Med, Alexandroupolis, Greece

[27] Univ Oxford, Oxford, England

[28] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil

[29] Gifu Municipal Hosp, Hematol, Gifu, Japan

[30] Kobe City Med Ctr, Dept Hematol, Gen Hosp, Kobe, Hyogo, Japan

[31] Gifu Univ, Dept Hematol, Gifu, Japan

[32] Kyoto Univ, Dept Hematol & Oncol, Kyoto, Japan

[33] Chugoku Cent Hosp, Dept Hematol, Fukuyama, Hiroshima, Japan

[34] King Chulalongkorn Mem Hosp, Div Hematol, Dept Med, Bangkok, Thailand

[35] Mem Sloan Kettering Canc Ctr, Leukemia Serv, Dept Med, New York, NY USA

[36] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[37] Vanderbilt Univ, Med Ctr, Program Canc Biol, Nashville, TN USA

[38] Inst Hematol & Blood Transfus, Prague, Czech Republic

[39] Hop St Louis, Inst Univ Hematol, Paris, France

[40] IRCCS Humanitas Res Hosp, Canc Ctr, Rozzano Milan, Italy

[41] Humanitas Univ, Rozzano Milan, Italy

[42] Univ York, Dept Heath Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England

[43] Mem Sloan Kettering Canc Ctr, Ctr Hematol Malignancies, 1275 York Ave, New York, NY 10021 USA

[44] Dana Farber, Data Sci Inst, Boston, MA USA

[45] Dana Farber Canc Inst, Data Sci Inst, Boston, MA 02115 USA

[46] Univ Paris 07, Hop St Louis, Serv Hematol Seniors, Paris, France

[47] Univ Hosp Dresden, Leipzig, Germany

[48] Med Univ Vienna, Div Hematol, Dept Internal Med 1, Vienna, Austria

[49] Med Univ Vienna, Ludwig Boltzmann Cluster Oncol, Vienna, Austria

[50] Univ Tsukuba, Dept Hematol, Tsukuba, Ibaraki, Japan

来源：

BLOOD | 2019年 / 134卷

关键词：

D O I：

10.1182/blood-2019-129392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

675

引用

页数：7