Malaria Is More Prevalent Than Iron Deficiency among Anemic Pregnant Women at the First Antenatal Visit in Rural South Kivu

被引:7
作者
Bahizire, Esto [1 ,2 ,3 ]
Tugirimana, P. Lundimu [4 ,5 ]
Dramaix, Michele [2 ]
Zozo, Deogratias [1 ]
Bahati, Mugisho [6 ]
Mwale, Andrew [3 ]
Meuris, Sylvain [7 ]
Donnen, Philippe [8 ]
机构
[1] Ctr Rech Sci Naturelles Lwiro, 343 Av PE, Bukavu, DEM REP CONGO
[2] Univ Libre Bruxelles, Ctr Res Epidemiol Biostat & Clin Res, Brussels, Belgium
[3] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya
[4] Natl Univ Rwanda, Dept Clin Biol, Kigali, Rwanda
[5] Univ Goma, Fac Med, Goma, DEM REP CONGO
[6] Div Provinciale Sante Sud Kivu, Bukavu, DEM REP CONGO
[7] Univ Libre Bruxelles, Lab Expt Hormonol, Brussels, Belgium
[8] Univ Libre Bruxelles, Ctr Res Hlth Policy & Syst Int Hlth, Brussels, Belgium
关键词
SOLUBLE TRANSFERRIN RECEPTOR; RISK-FACTORS; MICRONUTRIENT STATUS; MATERNAL ANEMIA; CHILDBEARING AGE; PLASMA FERRITIN; CHILDREN; PROTEIN; DETERMINANTS; TRANSMISSION;
D O I
10.4269/ajtmh.17-0267
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Anemia is common during pregnancy and is associated with poor outcomes. Objectives were not only 1) to determine the prevalence of anemia and iron deficiency (ID) but also 2) to identify other factors associated with anemia in pregnant women from South Kivu province, in the eastern Democratic Republic of Congo. Between December 2013 and March 2014, 531 women attending the first antenatal visit in their second trimester of pregnancy were recruited. Sociode-mographic, clinical, and biological data were collected. Hemoglobin (Hb) was determined by a portable photometer (Hemocue (R) Hb201+), and anemiawas defined as altitude-adjusted Hb < 110 g/L. ID was defined as serumferritin < 15 mu g/L adjusted for inflammation status (C-reactive protein [CRP] > 5 mg/L and/or alpha-1-acid glycoprotein > 1 g/L) whereas hypoalbuminemia was defined as serum albumin < 35 g/L. A Giemsa-stained blood smear was used to diagnose malaria. The median age (interquartile range) was 25.5 (21.1-31.3) years, with anemia in17.6% and ID in 8%. Malaria was present in 7.5% and hypoalbuminemia among 44%. Soluble transferrin receptor concentration was higher in the presence of inflammation and/or malaria. In the final logistic regression model, factors independently associated with anemia were malaria (adjusted odds ratio[aOR]: 11.24 (4.98-25.37) P<0.001), hypoalbuminemia [aOR: 2.14(1.27-3.59); P= 0.004] andelevatedCRP[aOR: 1.94(1.10-3.45); P= 0.022]. IDwas not highlyprevalent andnot associated with a nemia in our population. Effective control of anemia during pregnancy in this region should consider fighting malaria and other infectious diseases in combination with measures to improve women's nutrition, both before and during pregnancy.
引用
收藏
页码:1551 / 1560
页数:10
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