Spiro-heterocyclics: A convenient synthesis and antimicrobial activity of 3-(5-substituted phenyl-1,3,4-thiadiazole-2-yl)-5,8-dithiaspiro[3,4]octan-2-ones and 1,4-dithia-6-azaspiro[4,4]-nonan-7-ones

被引：0

作者：

Tiwari, Shailendra ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Allahabad 211002, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2018年 / 57卷 / 11期

关键词：

Substituted phenyl; 1,3,4-thiadiazole; dithiaspiro; azaspiro; antimicrobial antibacterial activity; antimicrobial antifungal activity; ANTIBACTERIAL ACTIVITY; DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of novel 3-(5-substituted phenyl-1,3,4-thiadiazole-2-yl)-5,8-dithiaspiro[3,4]octan-2-ones and 1,4-dithia-6-azaspiro[4,4]nonan-7-ones have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been determined for the test compounds as well as for reference standards. Compounds 4b, 4c, 4d, 5b, 5c, and 5d have shown good antibacterial activity whereas compounds 4b, 4d, 5b, and 5d have displayed better antifungal activity.

引用

页码：1416 / 1420

页数：5

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