Risk of Macrovascular Complications in Type 2 Diabetes Mellitus: Endothelial Microparticle Profiles

被引:49
作者
Jung, Keun-Hwa [1 ,2 ]
Chu, Kon [1 ,2 ]
Lee, Soon-Tae [1 ,2 ]
Bahn, Jae-Jun [1 ]
Kim, Jin-Hee [1 ]
Kim, Manho [1 ,2 ]
Lee, Sang Kun [1 ,2 ]
Roh, Jae-Kyu [1 ,2 ]
机构
[1] Seoul Natl Univ Hosp, Dept Neurol, Clin Res Inst, Seoul 110744, South Korea
[2] Seoul Natl Univ, Program Neurosci, Neurosci Res Inst SNUMRC, Seoul, South Korea
关键词
Type 2 diabetes mellitus; Cerebrovascular disease; Macroangiopathy; Endothelial microparticle; Risk factor; CORONARY-HEART-DISEASE; MICROVASCULAR COMPLICATIONS; GLYCOSYLATED HEMOGLOBIN; CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; ELEVATED LEVELS; DYSFUNCTION; STROKE; ARTERY;
D O I
10.1159/000324383
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: While the adverse impact of diabetes on microvessels is well known, the risks of macroangiopathy are less well recognized. Here, we determine the differential risk and endothelial microparticle (EMP) profile of vascular complications in type 2 diabetes mellitus. Methods: Macroangiopathy was evaluated for cerebrovascular disease, coronary artery disease and peripheral artery disease; microangiopathy was evaluated for retinopathy, nephropathy and peripheral neuropathy. Clinical and laboratory factors were compared among 149 patients with no vascular complications or with microangiopathic and/or macroangiopathic complications. EMPs were also examined by flow cytometry using CD31, CD42b, annexin V (AV), and CD62E antibodies in the peripheral blood of patients. Results: Diabetes of long duration, an elevated hemoglobin A1c (HbA1c) and concomitant hypertension were significantly associated with the occurrence of vascular complications. Dyslipidemia and a high body mass index were significantly associated with macroangiopathy, while diabetes of long duration and a high concentration of HbA1c were associated with microangiopathy. The EMP (CD31+/CD42b-, CD31+/AV+) levels were higher in patients with macroangiopathy than in patients with microangiopathy and no complications. The EMP level was also independently associated with macroangiopathy in diabetic patients. Conclusions: Microangiopathy and macroangiopathy in diabetic patients appear to have a different pathophysiological basis. The measurement of EMP would be helpful to differentiate the risk of diabetic vascular complications. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:485 / 493
页数:9
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