Pivotal trials of cardiac resynchronization therapy: evolution to therapy in mild heart failure

被引：4

作者：

Rickard, John ^{[2
]}

Wilkoff, Bruce Larry ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin, Cleveland, OH 44195 USA

[2] Cleveland Clin, Inst Heart & Vasc, Dept Cardiovasc Med, Cleveland, OH 44106 USA

来源：

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY | 2011年 / 31卷 / 01期

关键词：

Cardiac resynchronization therapy; Biventricular pacing; Heart failure; Cardiomyopathy; LEFT-VENTRICULAR DYSFUNCTION; INTRAVENTRICULAR-CONDUCTION DELAY; DISEASE PROGRESSION; COST-EFFECTIVENESS; REVERSE; SYMPTOMS; CARDIOMYOPATHY; DEFIBRILLATION; PREVENTION; MORTALITY;

D O I：

10.1007/s10840-011-9555-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac resynchronization therapy (CRT) has traditionally been reserved for patients with left ventricular (LV) dysfunction in the setting of advanced heart failure. Early clinical trials clearly demonstrated reverse ventricular remodeling and clinical benefits following CRT in this population. More recently, with the publication of the REVERSE, MADIT-CRT, and RAFT trials, the benefits of CRT have been demonstrated in patients with LV dysfunction and mild heart failure calling into question the optimal timing for biventricular pacemaker implantation. With the expanded indications for CRT arising from these studies, significant questions remain specifically with regards to the economic impact on health care systems and to the added risk of future morbidity due to device infection and malfunction.

引用

页码：61 / 68

页数：8

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