Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea

被引:27
作者
Park, Jun Seok [1 ]
Choi, Seulggie [2 ]
Kim, Kyuwoong [3 ]
Chang, Jooyoung [2 ]
Kim, Sung Min [2 ]
Kim, Seong Rae [1 ]
Lee, Gyeongsil [4 ]
Son, Joung Sik [4 ]
Kim, Kyae Hyung [4 ]
Lee, Eun Young [5 ]
Park, Sang Min [2 ,4 ]
机构
[1] Seoul Natl Univ Hosp, Coll Med, Seoul, South Korea
[2] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul, South Korea
[3] Natl Canc Ctr, Natl Canc Control Inst, Div Canc Control & Policy, Goyang, South Korea
[4] Seoul Natl Univ Hosp, Dept Family Med, Seoul, South Korea
[5] Seoul Natl Univ, Dept Internal Med, Div Rheumatol, Coll Med, Seoul, South Korea
关键词
rheumatoid arthritis; ankylosing spondylitis; systemic lupus erythematosus; particulate matter; epidemiology; SYSTEMIC-LUPUS-ERYTHEMATOSUS; AIR-POLLUTION EXPOSURES; COARSE PARTICLES; FINE PARTICLES; HUMAN HEALTH; ARTHRITIS; RISK; MORTALITY;
D O I
10.1093/rheumatology/keab127
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. The primary objective of this study was to investigate adverse effects of ambient particulate matter of various sizes on the incidence of the prevalent autoimmune rheumatic diseases (AIRDs): RA, AS and SLE. Methods. We investigated 230 034 participants in three metropolitan cities of South Korea from the National Health Insurance Service-National Sample Cohort (NHIS-NSC). Starting from January 2010, subjects were followed up until the first event of prevalent AIRDs, death, or December 2013. The 2008-2009 respective averages of particulate matter(2.5) (<2.5 mu m) and particulate matter(coarse) (2.5 mu m to 10 mu m) were linked with participants' administrative district codes. Adjusted hazard ratios (aHRs) and 95% CIs were estimated using Cox regression analysis in one- and two-pollutant models. Results. Adjusted for age, sex, region, and household income, in the two-pollutant model, RA incidence was positively associated with the 10 mu g/m(3) increment of particulate matter(2.5) (aHR = 1.74, 95% CI: 1.06, 2.86), but not with particulate matter(coarse) (aHR = 1.27, 95% CI: 0.87, 1.85). In the one-pollutant model, the elevated incidence rate of RA was slightly attenuated (particulate matter(2.5) aHR = 1.61, 95% CI: 0.99, 2.61; particulate matter(coarse) aHR = 1.13, 95% CI: 0.80, 1.61), with marginal statistical significance for particulate matter(2.5). The RA incidence was also higher in the 4th quartile group of particulate matter(2.5) compared with the first quartile group (aHR = 1.83, 95% CI: 1.07, 3.11). Adverse effects from particulate matter were not found for AS or SLE in either the one- or two-pollutant models. Conclusion. The important components of particulate matter(10) associated with RA incidence were the fine fractions (particulate matter(2.5)); no positive association was found between particulate matter and AS or SLE.
引用
收藏
页码:5117 / 5126
页数:10
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