Ketamine-induced rotational asymmetry in evaluation of motor disturbances in rats with middle cerebral artery occlusion

被引：4

作者：

Lebedev, SV ^{[1
]}

Petrov, SV ^{[1
]}

Blinov, DV ^{[1
]}

Lazarenko, IP ^{[1
]}

Chekhonin, VP ^{[1
]}

机构：

[1] VP Serbskii State Res Ctr Social & Forens Psychia, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 05期

关键词：

ketamine; middle cerebral artery occlusion; motor asymmetry; automatic rotameter;

D O I：

10.1023/A:1024946821482

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intraperitoneal injection of ketamine in subanesthetic doses to Wistar rats with unilateral occlusion of the middle cerebral artery caused ipsilateral rotation (2-10 rpm), which was recorded in an automatic rotameter. The optimal dose of ketamine was 50 mg/kg. The animals were examined in an automatic rotameter for 40 min. Motor asymmetry persisted for no less than 2 months after surgery. According to the neurological test (Menzies scale) motor asymmetry in animals with focal brain ischemia persisted for no more than 30 days. The degree of ketamine-induced motor asymmetry in intact rats was 0.10 +/- 0.03 rpm.

引用

页码：424 / 427

页数：4

共 10 条

[1] An alternative method for the quantitation of neuronal damage after experimental middle cerebral artery occlusion in rats: Analysis of behavioral deficit
Aronowski, J
Samways, E
Strong, R
Rhoades, HM
Grotta, JC
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (04) : 705 - 713
[2] Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats
Borlongan, CV
Tajima, Y
Trojanowski, JQ
Lee, VMY
Sanberg, PR
[J]. EXPERIMENTAL NEUROLOGY, 1998, 149 (02) : 310 - 321
[3] LOCOMOTOR AND PASSIVE-AVOIDANCE DEFICITS FOLLOWING OCCLUSION OF THE MIDDLE CEREBRAL-ARTERY
BORLONGAN, CV
CAHILL, DW
SANBERG, PR
[J]. PHYSIOLOGY & BEHAVIOR, 1995, 58 (05) : 909 - 917
[4] Breier A, 1997, AM J PSYCHIAT, V154, P805
[5] FUNCTIONAL-INTEGRATION OF CORTICAL GRAFTS PLACED IN BRAIN INFARCTS OF RATS
GRABOWSKI, M
BRUNDIN, P
JOHANSSON, BB
[J]. ANNALS OF NEUROLOGY, 1993, 34 (03) : 362 - 368
[6] CORRELATION OF REGIONAL BRAIN METABOLISM WITH RECEPTOR LOCALIZATION DURING KETAMINE ANESTHESIA - COMBINED AUTORADIOGRAPHIC 2-[H-3]DEOXY-DEUTERIUM-GLUCOSE RECEPTOR-BINDING TECHNIQUE
HAMMER, RP
HERKENHAM, M
PERT, CB
QUIRION, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (09): : 3067 - 3070
[7] MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS - A NEUROLOGICAL AND PATHOLOGICAL EVALUATION OF A REPRODUCIBLE MODEL
MENZIES, SA
SMITH, RR
HOFF, JT
BETZ, AL
[J]. NEUROSURGERY, 1992, 31 (01) : 100 - 107
[8] STRIATAL GRAFTS IN THE ISCHEMIC STRIATUM IMPROVE PALLIDAL GABA RELEASE AND PASSIVE-AVOIDANCE
NISHINO, H
KOIDE, K
AIHARA, N
KUMAZAKI, M
SAKURAI, T
NAGAI, H
[J]. BRAIN RESEARCH BULLETIN, 1993, 32 (05) : 517 - 520
[9] Semchenko V, 2000, TRANSPLANTATION IMMA
[10] Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7 -: II.: Effect on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of permanent middle cerebral artery occlusion in rats
Tamura, M
Aoki, Y
Seto, T
Itoh, Y
Ukai, Y
[J]. BRAIN RESEARCH, 2001, 890 (01) : 170 - 176

← 1 →