Stereoselective aza-Darzens reactions of tert-butanesulfinimines: convenient access to chiral aziridines

被引：24
|
作者：
Sola, Toni Moragas [1 ]
Churcher, Ian [2 ]
Lewis, William [1 ]
Stockman, Robert A. [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[2] GlaxoSmithKline Inc, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 14期
基金：
英国工程与自然科学研究理事会;
关键词：
N-SULFINYL IMINES; ASYMMETRIC-SYNTHESIS; ENANTIOPURE SULFOXIDES; SULFINIMINES; SULFINAMIDES; EPOXIDES; NITROGEN; AMINES;
D O I：
10.1039/c1ob05561e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stereoselective synthesis of 2,3-di- and 2,2',3-tri-substituted aziridines in good yields and excellent diastereoselectivities are achieved through aza-Darzens reactions of a range of tert-butanesulfinyl aldimines and ketimines with ethyl bromoacetate.
引用
收藏
页码：5034 / 5035
页数：2
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