Confirmation of dyslexia susceptibility loci on chromosomes 1p and 2p, but not 6p in a dutch sib-pair collection

被引：24

作者：

de Kovel, Carolien G. F. ^{[1
]}

Franke, Barbara ^{[1
]}

Hol, Frans A. ^{[1
]}

Lebrec, Jeremie J. P. ^{[2
]}

Maassen, Ben ^{[3
]}

Brunner, Han ^{[1
]}

Padberg, George W. ^{[4
]}

Platko, Jill ^{[5
]}

Pauls, David ^{[5
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands

[2] Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, Leiden, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, NL-6525 ED Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Neurol, NL-6525 ED Nijmegen, Netherlands

[5] Harvard Univ, Sch Med, Psychiat & Neurodev Unit, Boston, MA USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2008年 / 147B卷 / 03期

关键词：

dyslexia; affected sib-pairs; linkage; rapid naming; non-word reading;

D O I：

10.1002/ajmg.b.30598

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this study, we attempted to confirm genetic linkage to developmental dyslexia and reading-related quantitative traits of loci that have been shown to be associated with dyslexia in previous studies. In our sample of 108 Dutch nuclear families, the categorical trait showed strongest linkage to 1p36 (NPL-LOD=2.1). LOD scores for quantitative traits word-reading, non-word reading, and rapid naming peaked near the same location as the categorical trait, as well as on chromosome 2. Non-word repetition showed little phenotypic correlation with dyslexia or with the other quantitative traits, and this trait showed linkage peaks on 11p and 15q. No evidence for linkage to 6p22-23 was found for this set of families. Comparison of our results and literature data shows that loci link to different phenotypes in different samples. The mutual connections of these traits and their relation to developmental dyslexia remain elusive. (C) 2007 Wiley-Liss, Inc.

引用

页码：294 / 300

页数：7

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