How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein

被引：11

作者：

Wahl, Ilka ^{[1
]}

Wardemann, Hedda ^{[1
]}

机构：

[1] German Canc Res Ctr, Cell Immunol B, Heidelberg, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2022年 / 219卷 / 02期

关键词：

T-CELL EPITOPE; CXC CHEMOKINE RECEPTOR-5; MALARIA VACCINE; POLYMORPHIC REGIONS; ACQUIRED-IMMUNITY; GAMMA-GLOBULIN; TFH CELLS; SPOROZOITE; RECOGNIZE; INFECTION;

D O I：

10.1084/jem.20201313

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies against Plasmodium falciparum circumsporozoite protein (PfCSP) can protect from malaria. However, the efficacy of anti-PfCSP vaccine responses is limited. This review summarizes our molecular and cellular understanding of humoral anti-PfCSP immune responses and discusses implications for vaccine design. The induction of protective humoral immune responses against sporozoite surface proteins of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a preerythrocytic malaria vaccine. The most promising antibody target is circumsporozoite protein (CSP). Although PfCSP induces strong humoral immune responses upon vaccination, vaccine efficacy is overall limited and not durable. Here, we review recent efforts to gain a better molecular and cellular understanding of anti-PfCSP B cell responses in humans and discuss ways to overcome limitations in the induction of stable titers of high-affinity antibodies that might help to increase vaccine efficacy and promote long-lived protection.

引用

页数：10

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