Data-driven questionnaire-based cluster analysis of asthma in Swedish adults

被引：12

作者：

Kisiel, Marta A. ^{[1
]}

Zhou, Xingwu ^{[2
,3
,4
]}

Sundh, Josefin ^{[5
]}

Stallberg, Bjorn ^{[6
]}

Lisspers, Karin ^{[6
]}

Malinovschi, Andrei ^{[3
]}

Sandelowsky, Hanna ^{[7
]}

Montgomery, Scott ^{[8
,9
,10
]}

Nager, Anna ^{[7
]}

Janson, Christer ^{[2
]}

机构：

[1] Uppsala Univ, Dept Med Sci Environm & Occupat Med, Uppsala, Sweden

[2] Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden

[3] Uppsala Univ, Dept Med Sci Clin Physiol, Uppsala, Sweden

[4] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden

[5] Orebro Univ, Fac Med & Hlth, Dept Resp Med, Orebro, Sweden

[6] Uppsala Univ, Dept Publ Hlth & Caring Sci Family Med & Prevent, Uppsala, Sweden

[7] Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden

[8] Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden

[9] Karolinska Inst, Dept Med, Clin Epidemiol Div, Stockholm, Sweden

[10] UCL, Dept Epidemiol & Publ Hlth, London, England

来源：

NPJ PRIMARY CARE RESPIRATORY MEDICINE | 2020年 / 30卷 / 01期

关键词：

QUALITY-OF-LIFE; LUNG-FUNCTION; PHENOTYPES; IDENTIFICATION; ASSOCIATIONS; VALIDATION;

D O I：

10.1038/s41533-020-0168-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The aim of this study was to identify asthma phenotypes through cluster analysis. Cluster analysis was performed using self-reported characteristics from a cohort of 1291 Swedish asthma patients. Disease burden was measured using the Asthma Control Test (ACT), the mini Asthma Quality of Life Questionnaire (mini-AQLQ), exacerbation frequency and asthma severity. Validation was performed in 748 individuals from the same geographical region. Three clusters; early onset predominantly female, adult onset predominantly female and adult onset predominantly male, were identified. Early onset predominantly female asthma had a higher burden of disease, the highest exacerbation frequency and use of inhaled corticosteroids. Adult onset predominantly male asthma had the highest mean score of ACT and mini-AQLQ, the lowest exacerbation frequency and higher proportion of subjects with mild asthma. These clusters, based on information from clinical questionnaire data, might be useful in primary care settings where the access to spirometry and biomarkers is limited.

引用

页数：9

共 31 条

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