Decreased α-Synuclein Serum Levels in Patients with Lewy Body Dementia Compared to Alzheimer's Disease Patients and Control Subjects

被引：30

作者：

Laske, Christoph ^{[1
]}

Fallgatter, Andreas J. ^{[1
]}

Stransky, Elke ^{[1
]}

Hagen, Katja ^{[1
,3
]}

Berg, Daniela ^{[2
,3
]}

Maetzler, Walter ^{[2
,3
]}

机构：

[1] Univ Tubingen, Dept Psychiat & Psychotherapy, DE-72076 Tubingen, Germany

[2] Univ Tubingen, Dept Neurodegenerat, Ctr Neurol, Hertie Inst Clin Brain Res, DE-72076 Tubingen, Germany

[3] German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2011年 / 31卷 / 06期

关键词：

Dementia with Lewy bodies; Alzheimer's disease; Dementia; alpha-Synuclein; Serum; PARKINSONS-DISEASE; BODIES; CSF; DISCRIMINATE; DIAGNOSIS;

D O I：

10.1159/000329763

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: Detection and differentiation of neuro-degenerative dementias, such as dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), with blood-based biomarkers would facilitate diagnosis and treatment. Methods: By use of a commercially available ELISA kit, we measured alpha-synuclein levels in the serum of 40 DLB patients and controls, and of 80 AD patients. Results: We found significantly reduced alpha-synuclein serum levels in DLB compared to both AD (p = 0.006) and control subjects (p = 0.001), reaching an area under the curve of >0.70. Conclusion: Although these results do not justify a definition of serum alpha-synuclein as a potential single biomarker, results may contribute to a multimarker strategy in DLB diagnosis. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：413 / 416

页数：4

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