GLP-1 Suppresses Feeding Behaviors and Modulates Neuronal Electrophysiological Properties in Multiple Brain Regions

被引：29

作者：

Chen, Xin-Yi ^{[1
,2
]}

Chen, Lei ^{[3
]}

Yang, Wu ^{[1
]}

Xie, An-Mu ^{[2
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Dept Int Med, Qingdao, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Neurol, Qingdao, Peoples R China

[3] Qingdao Univ, Sch Basic Med, Dept Physiol & Pathophysiol, Qingdao, Peoples R China

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2021年 / 14卷

基金：

中国国家自然科学基金;

关键词：

GLP-1; electrophysiological property; feeding behavior; spontaneous firing activity; synaptic transmission; GLUCAGON-LIKE PEPTIDE-1; VENTRAL TEGMENTAL AREA; REDUCES FOOD-INTAKE; NUCLEUS-ACCUMBENS; ARCUATE NUCLEUS; NEURAL-CONTROL; RECEPTOR; ACTIVATION; HYPOTHALAMUS; EXCITABILITY;

D O I：

10.3389/fnmol.2021.793004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The glucagon-like peptide-1 (GLP-1) plays important roles in the regulation of food intake and energy metabolism. Peripheral or central GLP-1 suppresses food intake and reduces body weight. The electrophysiological properties of neurons in the mammalian central nervous system reflect the neuronal excitability and the functional organization of the brain. Recent studies focus on elucidating GLP-1-induced suppression of feeding behaviors and modulation of neuronal electrophysiological properties in several brain regions. Here, we summarize that activation of GLP-1 receptor (GLP-1R) suppresses food intake and induces postsynaptic depolarization of membrane potential and/or presynaptic modulation of glutamatergic or GABAergic neurotransmission in brain nuclei located within the medulla oblongata, pons, mesencephalon, diencephalon, and telencephalon. This review may provide a background to guide future research about the cellular mechanisms of GLP-1-induced feeding inhibition.

引用

页数：9

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