Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

被引：570

作者：

Orava, Janne ^{[1
]}

Nuutila, Pirjo ^{[1
,3
]}

Lidell, Martin E. ^{[8
]}

Oikonen, Vesa ^{[1
]}

Noponen, Tommi ^{[4
]}

Viljanen, Tapio ^{[1
]}

Scheinin, Mika ^{[2
,7
]}

Taittonen, Markku ^{[5
]}

Niemi, Tarja ^{[6
]}

Enerback, Sven ^{[8
]}

Virtanen, Kirsi A. ^{[1
]}

机构：

[1] Univ Turku, Turku PET Ctr, Turku, Finland

[2] Univ Turku, Dept Pharmacol Drug Dev & Therapeut, Turku, Finland

[3] Univ Turku, Dept Med, Turku, Finland

[4] Turku Univ Hosp, Dept Nucl Med, Turku 20521, Finland

[5] Turku Univ Hosp, Dept Anesthesiol, Turku 20521, Finland

[6] Turku Univ Hosp, Dept Surg, Turku 20521, Finland

[7] Turku Univ Hosp, TYKSLAB, Clin Pharmacol Unit, Turku 20521, Finland

[8] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med & Clin Genet, S-40530 Gothenburg, Sweden

来源：

CELL METABOLISM | 2011年 / 14卷 / 02期

基金：

芬兰科学院; 瑞典研究理事会;

关键词：

BLOOD-FLOW; THERMOGENESIS; ADIPOCYTE; GENE; FAT;

D O I：

10.1016/j.cmet.2011.06.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated the metabolism of human brown adipose tissue (BAT) in healthy subjects by determining its cold-induced and insulin-stimulated glucose uptake and blood flow (perfusion) using positron emission tomography (PET) combined with computed tomography (CT). Second, we assessed gene expression in human BAT and white adipose tissue (WAT). Glucose uptake was induced 12-fold in BAT by cold, accompanied by doubling of perfusion. We found a positive association between whole-body energy expenditure and BAT perfusion. Insulin enhanced glucose uptake 5-fold in BAT independently of its perfusion, while the effect on WAT was weaker. The gene expression level of insulin-sensitive glucose transporter GLUT4 was also higher in BAT as compared to WAT. In conclusion, BAT appears to be differently activated by insulin and cold; in response to insulin, BAT displays high glucose uptake without increased perfusion, but when activated by cold, it dissipates energy in a perfusion-dependent manner.

引用

页码：272 / 279

页数：8

共 26 条

[1] Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia [J].