Role of lncRNAs in Cellular Aging

被引：33

作者：

Degirmenci, Ufuk ^{[1
,2
]}

Lei, Sun ^{[1
,3
]}

机构：

[1] Agcy Sci Technol & Res, Inst Mol & Cell Biol, Singapore, Singapore

[2] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore

[3] Duke NUS, Programme Cardiovasc & Metab Disorders, Singapore, Singapore

来源：

FRONTIERS IN ENDOCRINOLOGY | 2016年 / 7卷

基金：

新加坡国家研究基金会;

关键词：

senescence; aging; lncRNA; SASP; p21; p53; p16; PRC; LONG NONCODING RNAS; DNA-DAMAGE RESPONSE; REPEAT-CONTAINING RNA; AGE-RELATED DISEASE; REPLICATIVE SENESCENCE; APOPTOSIS RESISTANCE; GENE-EXPRESSION; DOWN-REGULATION; CELLS REVEALS; EMERGING ROLE;

D O I：

10.3389/fendo.2016.00151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.

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页数：10

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